Is Hydroxyethyl Starch Safe in Penetrating Trauma Patients?
نویسندگان
چکیده
منابع مشابه
Hydroxyethyl starch in patients with trauma.
Editor—The Fluids in Resuscitation of Severe Trauma (FIRST) randomized trial conducted by James and colleagues compared hydroxyethyl starch (HES) 130/0.4 with 0.9% saline in the resuscitation of 115 patients with severe blunt or penetrating trauma at a single centre in South Africa. In blunt trauma, which accounts for 86–97% of all traumatic injuries in Europe, 3 no differences were found betwe...
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It is heavily debated whether or not treatment with hydroxyethyl starch 130/0.4 contributes to the development of acute kidney failure in patients with severe sepsis. In the previous issue of Critical Care, Muller and colleagues report no association between initial resuscitation with hydroxyethyl starch 130/0.4 and renal impairment in a cohort of septic patients. Can we then consider hydroxyet...
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Anesthesiology, V 123 • No 2 481 August 2015 To the Editor: The title of the publication by Kancir et al.1 implies lack of nephrotoxicity associated with the use of either 6% hydroxyethyl starch 130/0.4 or 0.9% NaCl during hip arthroplasty. The primary outcome variable was urinary concentrations of neutrophil gelatinase–associated lipocalin (u-NGAL). For all observation points, u-NGAL concentra...
متن کاملResuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma).
BACKGROUND The role of fluids in trauma resuscitation is controversial. We compared resuscitation with 0.9% saline vs hydroxyethyl starch, HES 130/0.4, in severe trauma with respect to resuscitation, fluid volume, gastrointestinal recovery, renal function, and blood product requirements. METHODS Randomized, controlled, double-blind study of severely injured patients requiring >3 litres of flu...
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we reported were in compliance with the Victoria DHS Guidelines for DES, which fall within the FDA guidelines, and therefore do not constitute ‘off-label’ use. With respect to the protocol developed in the Geelong Hospital, we assumed that the DES was a ‘high-risk lesion’ in the coronary circulation and devised a treatment regimen to reduce the risk of coronary occlusion while at the same time ...
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ژورنال
عنوان ژورنال: Military Medicine
سال: 2016
ISSN: 0026-4075,1930-613X
DOI: 10.7205/milmed-d-15-00132